SDP5: Sweden’s CAR-T Cell Competence Network (SWECARNET)
Lead: Karolinska Institutet, LABMED and Karolinska Universitetssjukhuset, CAST
Involved partners: Uppsala Universitet, Skånes Universitetssjukhus, Sahlgrenska Universitetssjukhuset, Karolinska Institutet, Karolinska Universitetssjukhuset, Novartis Sverige AB, Celgene AB, Gilead Science Sweden AB
Aims: to create a platform and network for clinical use of CAR T-cells in Sweden.
Examples of tasks and actions:
- Develop guidelines including indications and the implementation of CAR-T cells into the patient flows within one diagnose group
- Develop guidelines and SOPs of how to apply and followup CAR-T therapies and how to submit data to EBMT database – provide educational program
- Develop SWECARNET app
Interview with project leader
Hi Stephan Mielke!
What is the need your project addresses?
The fast track translation of CAR-T therapies creates significant challenges for both regulators and healthcare providers due to uncertainty in poorly understood, potentially life threatening side effects and unknown longterm effects. With few European clinicians with hands on experience in delivery and followup of CAR-T therapies, networks of experts are needed to ensure establishment of critical guidelines, education and SOPs for standardised delivery and data collection, ensuring optimal performance and development of these therapies.
What is your approach to meet the need?
We are networking key persons in the Swedish CAR-T field, within companies, healthcare, competent authorities and regulatory bodies, towards knowledge exchange and development of standardised processes for CAR-T delivery and follow up. This network will work closely with the Regional Cancer Center (RCC) and the Swedish Norwegian Bone Marrow transplant group (SNBMTG) to create guidelines and recommendations based on the novel nature of CAR-T therapies, but drawing from established expertise in allogeneic stem cell transplantation.
How will this improve Sweden´s capabilities within ATMPs?
Strategies developed within this network will ensure the processes by which healthcare facilities are approved to deliver CAR-Ts are streamlined and that once approved healthcare staff will be have the resources they need to ensure optimal performance of these product. This means not only more patients receiving potentially life saving treatments but in more locations in Sweden to minimise burden of treatment on the patient. Sweden has some of the world’s best outcomes from CAR-T treatments and the resources developed within this network will ensure that quality is not lost for the sake of quantity. In a general sense the lessons learned, information shared and processes developed through this CAR-T network will build competence within healthcare personel, competent authorities and regulatory bodies who will then be more capable of implementing other ATMPs to Swedish healthcare.
For more information please contact Stephan Mielke