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Gene-editing tool used for making highly specific genomic modifications, consisting of a specifically designed piece of guide RNA (gRNA), which is used to recognize a specific DNA sequence that bears a palindromic repeat, and a Cas9 enzyme to cut at a specific site and remove a piece of genomic DNA, ready for the introduction of a new DNA sequence.


En genomredigeringsteknik som bland annat kan användas för att skapa riktade mutationer i arvsmassan.


Resources and references

Definitions have been translated into the Swedish language from the following sources:

  1. 1. American Society of Gene and Cell Therapy Glossary
  2. 2. Clinical Trials Information System
  3. 3. EMA Glossary of Regulatory Terms
  4. 4. EMA Medical Terms simplifier
  5. 5. Glossary of Terms used in EU Clinical Trials Register
  6. 6. Glossary of Terms U.S Food and Drug Administration
  7. 7. National Human Genome Research Institute “Talking Glossary of Genomic and Genetic Terms”
  8. 8. The Glossary for Advanced Therapies Regen. Med. Dec 2020 Vol. 15 No. 12 Suppl. 1
  9. 9. Toolkit For Patient Focused Therapy Development Glossary

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