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gammadelta T cell (γδ T cell)

gammadelta T cell [ENGLISH]

Gamma delta T cells (γδ T cells) are T cells that have a γδ T-cell receptor (TCR) on their surface. Most T cells are αβ (alpha beta) T cells with TCR composed of two glycoprotein chains called α (alpha) and β (beta) TCR chains. In contrast, γδ T cells have a TCR that is made up of one γ (gamma) chain and one δ (delta) chain. This group of T cells is usually less common than αβ T cells. Their highest abundance is in the gut mucosa, within a population of lymphocytes known as intraepithelial lymphocytes (IELs).

gammadelta T cell [SWEDISH]

γδ-T-celler, (gamma-delta-T-celler) utgör en liten del av T-cellerna, och har en speciell typ av T-cellsreceptor (TCR) på sin yta. En majoritet av T-cellerna har en TCR bestående av två glykoproteinkedjor, α- och β-TCR. Men i γδ T-celler består T-cellsreceptorn av en γ-kedja och en δ-kedja. Denna grupp av T-celler är mycket ovanligare (5 % av det totala antalet T-celler) än αβ T-celler, och förekommer främst i tarmen, i en grupp av lymfocyter som kallas intraepiteliala lymphocyter (IEL:s).


Resources and references

Definitions have been translated into the Swedish language from the following sources:

  1. 1. American Society of Gene and Cell Therapy Glossary
  2. 2. Clinical Trials Information System
  3. 3. EMA Glossary of Regulatory Terms
  4. 4. EMA Medical Terms simplifier
  5. 5. Glossary of Terms used in EU Clinical Trials Register
  6. 6. Glossary of Terms U.S Food and Drug Administration
  7. 7. National Human Genome Research Institute “Talking Glossary of Genomic and Genetic Terms”
  8. 8. The Glossary for Advanced Therapies Regen. Med. Dec 2020 Vol. 15 No. 12 Suppl. 1
  9. 9. Toolkit For Patient Focused Therapy Development Glossary

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