Projects

Projects within CAMP cover scientific, technological and infrastructure challenges around process development and production of ATMP.

Twenty collaboration projects engaging partners from healthcare, industry and academy have been, or are currently running within CAMP.

Current project portfolio

Automated manufacturing of ATMPs

Project leader: Malin Parmar, Lund University
Project partners: Lund University, Skåne University Hospital, Miltenyi Biotec

Development of Multilayered Tissue-Engineered Skin Construct

Project leader: Folke Sjöberg, Region Östergötland
Project partners: Region Östergötland, Region Västerbotten, Umeå University, Cellastra, VivaBioCell, Xintela

GMP production of pluripotent stem cells and its derivatives

Project leader: Anders Lindahl, University of Gothenburg
Project partners: University of Gothenburg, Karolinska Institutet, Umeå University, Region Västerbotten, Vecura/Karolinska Universitetssjukhuset, Takara Bio Europe, VERIGRAFT

Extracellular vesicles (CARMEV) for prevention of heart failure

Project leader: Karl-Henrik Grinnemo, Akademiska Sjukhuset
Project partners: Akademiska sjukhuset, Uppsala University, AstraZeneca, Mitosense

Personalised ATMP for the regeneration of arteries

Project leader: Joakim Håkansson, RISE Research Institutes of Sweden
Project partners: RISE, University of Gothenburg, Västra Götalandsregionen, VERIGRAFT, Your Special Delivery Service

Fully closed (from vein to vein) and automated CAR-T manufacturing process

Project leader: Di Yu, Uppsala University
Project partners: Uppsala University, Vecura/Karolinska University Hospital, Elicera Therapeutics

Amniotic derived cell therapy improving outcome in lung transplantation

Project leader: Sandra Lindstedt, Skåne University Hospital
Project partners: Skåne University Hospital, Lund University, Amniotics

GMP-compliant infrastructure and production of mesenchymal stromal cells from lipoaspirate

Project leader: Peter Tropp, Region Örebro län
Project partners: Region Örebro län, Region Västerbotten, Acousort, VivaBioCell

Pre-GMP development of ATMPs and other gene-based strategies

• Subproject 1. GMP education and training courses focused on ATMPs
• Subproject 2. Development of HQ plasmid production
• Subproject 3. Development of small-medium scale viral vector production
• Subproject 4. Development of genetically modified T cells
• Subproject 5. Multi-use RNA production platform for A/GTMPs

Project leader: Matti Sällberg, Karolinska Institutet
Project partners: Karolinska Institutet, Vecura/Karolinska University Hospital, Lund University, Umeå University, Uppsala University, Region Västerbotten, Cytiva, Key2Compliance, NorthX Bio, SVF Vaccines

Vecura/KCC – an infrastructure for manufacturing of ATMPs

• Subproject 1. Expansion of GMP Compliant Tumor Infiltrating Lymphocytes (TILs) in Xuri bioreactor
• Subproject 2. Expansion of GMP-compliant adaptive T-cells in bioreactor
• Subproject 3. Cell processing of NK-cells using Sepax cell processing instrument

Project leader: Pontus Blomberg, Vecura/Karolinska University Hospital
Project partners: Vecura/Karolinska University Hospital, Karolinska Institutet, Cytiva, NEOGAP, XNK Therapeutics

Completed projects

1. Scaleable magnetic isolation of differentiated stem cells
2. QC and logistics – The Logistics Cookbook
3. Label-free sorting of stromal cell preparations for clinical use
4. ATMP for urethra reconstruction with de- and recellularization technique
5. CAR-T cell therapy for malignant melanoma of the skin and the eye
6. Value survey – How do donors, patients, the general public and policy makers want to balance different interests?
7. Development of producer lines for delivering therapeutic mRNAs through Extracellular Vesicles
8. Single cell qPCR characterization of ATMP
9. Establishing a non-dry ice dependent logistics strategy for cell therapies
10. Establishing a QC and logistics strategy of cell-based products for secure patient treatment