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Welcome to Uppsala

2023-10-17

Our annual conference in Sweden's oldest and thriving scientific melting pot

This years ATMP Sweden national conference is being held in Uppsala! You may not know the exceptional scientific history of this town, from Olof Rudbeck, Anders Celsius and Carl Linnaeus, to the nobel prize winning invention of the first chromatography medium in the world, Sephadex, launched in 1959 and still produced in Uppsala. Join us now for a little tour of Uppsala today and past to get you a little bit excited of what you can learn and what has been during our ATMP Sweden 2023 conference.

Please register to the Dec 5/6 conference soon to avoid missing out! ATMP – ATMP Sweden 2023 Uppsala!…..there are only 30 spots left!

Today, Uppsala is a strong hub for innovation where many research ideas developed in academia have become spin-out companies, including Lokon Pharma, Ilya Pharma and Elicera Therapeutics in the ATMP field. The clinical use of immunotherapy and cell transplantation is a strong tradition for Uppsala, for instance; islet cell transplantation in diabetes or autologous blood transplant for treatment of multiple sclerosis (MS) that, although not classified as ATMPs, mean an established history in clinical implementation and innovation of cellular therapies.

There has always been close collaboration between Uppsala University och Uppsala University Hospital, so it’s no surprise that ATMP center Uppsala was launched as a shared initiative of Uppsala University, Uppsala University Hospital and Region Uppsala. This center has a coordinating function within the health care system that aims to support researchers and health care professionals in the development and implementation of ATMP. ATMP center Uppsala was inaugurated on the 8th of September 2023 (Gunilla Enblad, Coco Norén, Malin Sjöberg, Eva Tiensuu Janson pictured right), yet some of the ATMP activities at Uppsala University hospital started already in the 1980’s. For instance, the hospital treats patients with autologous keratinocytes, a product currently under the hospital exemption, with a mandate for national specialized medical care (NHV) of patients with severe burn injuries. Uppsala University Hospital has a long-standing experience of treating patients with ATMP, both in clinical trials and with commercial products. The first clinical trial in Europe treating patients with CAR T cell therapy was conducted here in 2014. At least 21 clinical trials with ATMP products have been initiated at Uppsala University Hospital, both academic and industry initiated, of which 11 are ongoing. 3 additional clinical trials are planned to start in the beginning of 2024.

You will soon have the possibility to explore Uppsala further since ATMP center Uppsala are integral in the ATMP Sweden 2023 conference, 5-6th of December this year. The center will also host a local symposium lead by Prof. Gunilla Enblad and Prof. Magnus Essand in the afternoon of the 6th of December.

Get in touch with ATMP center Uppsala or learn more about Sweden’s ATMP center network here.

During the ATMP Sweden 2023 conference participants are also offered a guided tour of Testa Center. Testa Center is an initiative between the Swedish government and Cytiva to secure the growth of the life science industry and its manufacturing capabilities. Cytiva is recognized as a world leader in delivering preparative protein purification solutions to the life science community. 75% of FDA-approved biotherapeutics manufactured are using their technologies, for instance ÄKTA that is an Uppsala-original system from Pharmacia. Read more about the history of Pharmacia/GE Healthcare/Cytiva here.

Some tips to visit while you are in Uppsala: Take a walk in the city center and visit the Linnaeus Garden, continue along the river and head towards Uppsala Castle and Uppsala Cathedral – look up and we guarantee you’ll see the Castle on the skyline at the hill ‘Kasåsen’. Enjoy the view from the Castle by the Gunilla bell that has chimed twice a day for hundreds of years. Opposite to the Cathedral you´ll find Gustavianum (pictured left), that is currently closed for renovation, but you can still see the beautiful dome on top of the building that holds the anatomical theatre that was built in the 1660’s for dissections in front of an audience. And a little further up the hill you find the Uppsala University Hall and the Uppsala University library, Carolina Rediviva, that harbors the silver bible (Codex argenteus) in its collections.

More tips: The official visitor guide to Uppsala – Destination Uppsala

 

A LONG HISTORY OF WORLD LEADING SCIENCE

Uppsala University was the first Scandinavian University, opened in 1477. As you can imagine, this long history has resulted in some of the greatest scientific discoveries of all time, think;

  • Olof Rudbeck the elder – a pioneer of anatomy, in particular the lymphatic vessels in the 1650’s. In 1662 Rudbeck added another floor to the Gustavianum building and constructed an anatomical theatre (pictured right), for dissections in front of an audience of 200, inside a dome in the roof. The theatre remains and is now the second-oldest in the world.
  • Anders Celsius, born in 1701 in Uppsala. Scientist and astronomer best known for the Celsius temperature scale used in thermometers throughout the world.
  • Carl Linnaeus, the ’father of taxonomy’, moved to Uppsala in 1728. A botanist who created a system for biological classification and naming, the basis of which is still used today throughout the scientific world.

Among the University’s alumni there are 16 Nobel Prize laureates, 8 received their prizes for discoveries made during their time at Uppsala University. Notably, 4 of these awards form the basis of a long history of pharmaceutical development in Uppsala;

  • The Svedberg, Nobel Prize in Chemistry in 1926. Constructed the first ultracentrifuge for determining the size and form of various macromolecules, a separation method that has been of immense value to biochemistry and molecular biology.
  • Arne Tiselius,  Nobel Prize in Chemistry in 1948. The method he devised, electrophoresis of proteins, played a major role in establishing Uppsala as a leader in biochemical separation methods.
  • Manne Siegbahn, Nobel Prize in Physics in 1924 for his contributions to X-ray spectroscopy and Kai Siegbahn, Nobel Prize in Physics in 1981 for his work in high-resolution electron spectroscopy that provided an important analytical method for studying the effects of chemical binding.

While there’s a clear male dominance in this history section….globally rife not so long ago….it was in fact Uppsala University where Sweden’s first student association for women was founded in the 1890s by female students. It’s great to see now that 2 of the 3 listed ATMPs SMEs spinning out from Uppsala research have female CEOs (Angelica Loskog of Lokon Pharma and Evelina Vågesjö of Ilya Pharma), that Gunilla Enblad was the Principal Investigator for the above mentioned first European academic CAR T clinical trial and Coco Norén is the Deputy Vice-Chancellor of Uppsala University.

Past and modern, Uppsala is a city of innovation, a pioneer in pharmaceutical manufacture. We welcome you to Uppsala and hope to harness the energy of this town to inspire the next innovations!